Although the approval of Z圜oV-D from Indian pharma Zydus Cadila represents a historic first for DNA-based vaccines, peer-reviewed data describing the safety and efficacy of the spike-protein-encoding vaccine have yet to be published. ![]() The Emergency Use Authorization of a DNA-based COVID-19 vaccine by India’s regulator is a milestone for a nucleic acid technology that has been largely overlooked during the pandemic. India’s Z圜oV-D vaccine uses circular DNA to protect against SARS-CoV-2 infection.
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